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Megaderm: Frequently Asked Questions

What is Megaderm?

Megaderm has been developed to optimise the synergistic effects of Omega 6 and Omega 3. It is an Essential Fatty acid supplement for dogs and cats.

How does Megaderm differ from EFA –Z?

Megaderm is a more focused option to consider for managing pruritus. Megaderm contains a 5:1 ratio of Omega 6 to Omega 3. There is expert opinion supporting that this is the appropriate ratio. Much more Omega 3 is required than in EFA-Z to influence the inflammatory cascade. EFA-Z has a ratio of 40:1 Omega 6 to Omega 3 so it is more focused on keeping coat quality maintained and preventing seborrhoea.

How does Megaderm influence inflammatory skin conditions?

Megaderm limits the outcome of the inflammatory processes by modifying EFA metabolism in the skin. This influences the metabolic pathways of Poly-unsaturated fatty acids (PUFAs) that are involved in the inflammatory cascade. Activity is achieved by depriving the inflammatory process of its initial substrate (the arachidonic acid, W 6), inhibiting its potential metabolic conversions, and diverting the metabolic pathways towards fatty acids that will produce anti-inflammatory (or less inflammatory) mediators instead of pro-inflammatory mediators.

Why use Omega 6 and Omega 3?

The synergistic effects of W 6 and W 3 EFAs are beneficial as well in restoring skin integrity and providing an anti-inflammatory effect, by the control of PUFAs metabolic pathways.

Omega 6 are well described for maintaining good coat quality by maintaining water balance and cell integrity, modifying cell proliferation, and maintaining lustre whilst minimising seborrhoea.

In contrast Omega 3 has limited specific coat quality activity but is a key influencer of the inflammatory cascade.

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