Health Care

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A look inside cattle after injecting Multimin Evolution

Already with dozens of peer-reviewed publications from some of the world’s most recognised universities, and over 90 million doses trialled on real farms, MULTIMIN EVOLUTION INJECTION FOR CATTLE is the single most proven multi-trace mineral injection formulation of its type in the world.

A recent study conducted by Dr Roberto Palomares and his research team at the University of Georgia1 allocated cattle into one of three treatment groups. One group received a vaccine against bovine respiratory disease (BRD). The second group received the same vaccine but was also treated with MULTIMIN EVOLUTION. The third group acted as a control and did not receive the vaccine or MULTIMIN EVOLUTION. Each animal was then challenged with live viruses that cause BRD and later examined with an endoscopy camera to see what was happening in their respiratory tract.

Understandably, animals not given a vaccine showed the most severe reaction to BRD virus challenge. They showed high levels of inflammation (redness) and pus. Animals given a vaccine fared much better with significantly less inflammation and pus. However, the group treated with MULTIMIN EVOLUTION at the same time as a vaccine, performed the best – showing barely visible inflammation or pus.

Footage taken from the study can be viewed here:

The outcomes from this study indicate that the MULTIMIN EVOLUTION formula is highly effective in providing cattle with the trace minerals required to mount an effective immune response. This study is the first that demonstrated how an injectable trace mineral formulation has worked after a viral challenge and highlights the benefits unique to MULTIMIN EVOLUTION.

Although Dr Palomares’ work is specific to BRD, MULTIMIN EVOLUTION has been shown to be effective in improving the overall health of cattle, which has flow-on effects to help prevent many economically significant diseases. Published studies have demonstrated improvements in several markers of immune function, such as increased antioxidant levels, improved white blood cell function, and antibody responses 2-17. In addition, studies have also shown a reduced incidence of various diseases and illnesses, such as scours, pneumonia, and mastitis2-4. Fewer diseases have clear productivity benefits and result in reduced input costs, such as antibiotics and other veterinary treatments19.

In addition to supplying a rapidly absorbed top-up of trace minerals such as copper, selenium, and manganese, MULTIMIN EVOLUTION also provides enhanced levels of zinc, much higher than any other available product in the Australian market. Although all these minerals are essential for cattle health and optimal immunity, zinc has been shown by experts to be the trace mineral required in far higher quantities, especially for modern high performing cattle20,21.

MULTIMIN EVOLUTION is now available at most rural retailers. For more information, visit MULTIMIN EVOLUTION for a free information pack.

  1. Hoyos-Jaramillo et. al. (2019) Health status and endoscopic evaluation of the upper respiratory tract of dairy bull calves inoculated with BVDV2 and BHV1 after vaccination and trace minerals injection. Proceedings Steeve Giguère Science of Veterinary Medicine Symposium October 10, 2019 University of Georgia.
  2. Machado, V. et al. (2013). Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on the health and production of lactating Holstein cows. Vet. J. 197:4516.
  3. Teixeira, A. et al. (2014). Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves. J. Dairy Sci., 97:4216-4226.
  4. Ganda et al (2016). Effects of injectable trace mineral supplementation in lactating dairy cows with elevated somatic cell counts. J. Dairy Sci., 99(9), 7319-7329
  5. Berry et al. (2000). Efficacy of Multimin in Improving Performance and Health in Receiving Cattle. Oklahoma State University Animal Science Report, 980:61-64.
  6. Richeson, J. et al. (2006). Supplemental trace minerals from injection for shipping-stressed cattle. AAES Research Series, 574: 85-88.
  7. Arthington, J. et al. (2014). Effects of trace minerals on measures of performance and trace mineral status of pre- and post-weaned beef calves. J. Anim. Sci., 92:2630-2640.
  8. Arthington, J. D., & Havenga, L. J. (2012). Effect of injectable trace minerals on the humoral immune response to multivalent vaccine administration in beef calves. J. Anim. Sci., 90(6), 1966-1971.
  9. Roberts, S. L. et al (2016). Effect of injectable trace mineral administration on health, performance, and vaccine response of newly received feedlot cattle. The Professional Animal Scientist, 32(6), 842-848.
  10. Palomares, R. et al. (2016). Effects of injectable trace minerals on humoral and cell-mediated immune responses to Bovine Viral Diarrhea Virus, Bovine Herpes Virus 1 and Bovine Respiratory Syncytial Virus following administration of a modified-live virus vaccine in dairy calves. Vet. Immunol. Immunopathol., 178:88-98.
  11. Ball, M. (2016). Trace mineral injection enhances antibody response to botulism vaccination. AVA Proceedings, Adelaide*.
  12. Bittar, J. H. et al (2020). Immune response and onset of protection from Bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves. Vet. Immunol. Immunopathology, 110055.
  13. Bittar, J. H. J. et al (2018). Effects of injectable trace minerals administered concurrently with a modified live virus vaccine on long-term protection against bovine viral diarrhea virus acute infection in dairy calves. Res. Vet. Sci., 119, 250-258.
  14. Bittar, J. H. et al (2018). Effects of injectable trace minerals on the immune response to Mannheimia haemolytica and Pasteurella multocida following vaccination of dairy calves with a commercial attenuated-live bacterin vaccine. The Professional Animal Scientist, 34(1), 59-66.
  15. Bates A, et al. (2019). Reduction in morbidity and mortality of dairy calves from an injectable trace mineral supplement. Vet Rec. 184(22):680*
  16. Bates, A., et al (2020). Effect of an injectable trace mineral supplement on the immune response of dairy calves. Res. Vet. Sci., 130, 1-10*.
  17. Hansen (2010) Effects of Multimin®90 on trace mineral status of Angus and Simmental calves. Iowa State University, Department of Animal Science.
  18. Guest K (2019) Effects of trace minerals on the immune response to bovine coronavirus and rotavirus vaccination in dairy cows #17. Proceedings Steeve Giguère Science of Veterinary Medicine Symposium October 10, 2019, University of Georgia. 
  19. Berry et al (2000), Oklahoma State University Animal Science Report P-980:61-64*
  20. Spears, J. W. (2002). Overview of mineral nutrition in cattle: the dairy and beef NRC. In 13th Annual Florida Ruminant Nutrition Symposium, University of Florida, Gainesville (pp. 113-126).
  21. Weiss, W. P. (2017). A 100-Year Review: From ascorbic acid to zinc—Mineral and vitamin nutrition of dairy cows. J. Dairy Sci., 100(12), 10045-10060.

    *The Multimin® formulation in this study contained lower levels of minerals compared to Multimin® Evolution. Benefits determined by these scientific trials are not necessarily registered label claims. ®Multimin is a registered trademark of Virbac.

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